The aim of present investigation was to develop compression coated tablet of rifampicin and isoniazide to minimize degradation of rifampicin in acidic medium and to modulate the release of rifampicin in the stomach and isoniazide in intestine. Tablets of rifampicin were prepared by wet granulation using PVP K-30, isopropyl alcohol, micro crystalline cellulose, cross carmeloss sodium, talc and magnesium stearate. The powder blend and tablets of rifampicin were characterized. Isoniazide tablets, prepared by wet granulation using dicalcium phosphate, were enteric coated using eudragit S100 and tablets of isoniazide were characterized. Compressed tablets of rifampicin and isoniazide were prepared and characterized for in-vitro drug release and modified dissolution method studies. Rifampicin and isoniazide was released at pH 1.2 up to 2hr from the dosage form. Less than 1% of isoniazide was released at pH 1.2 from dosage form before reaching to intestinal pH 7.4. Complete release of isoniazide was observed within 90 to 120 min at pH 7.4. Also, degradation of rifampicin was less in modified dissolution method compare to USP paddle apparatus.
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